Does Olmesartan Medoxomil Hydrochlorothiazide Interact with Aliskiren?
Olmesartan Medoxomil Hydrochlorothiazide and Aliskiren have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not co-administer aliskiren with BENICAR HCT in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure. The mechanism involves dual ras inhibition leads to excessive suppression of the renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Olmesartan Medoxomil Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Olmesartan Medoxomil Hydrochlorothiazide and Aliskiren occurs because dual ras inhibition leads to excessive suppression of the renin-angiotensin system. Clinically, this means do not co-administer aliskiren with benicar hct in patients with diabetes. avoid use in patients with renal impairment (gfr <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Olmesartan Medoxomil Hydrochlorothiazide and your doctor is considering prescribing Aliskiren (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider