Home›Drug Classes›Atypical Antipsychotics

Atypical Antipsychotics

Atypical antipsychotics treat schizophrenia, bipolar disorder, and depression. They carry interaction risks with CNS depressants, QT-prolonging drugs, and CYP450 inhibitors.

16 drugs in this class6 notable interactions shown

Atypical Antipsychotics Drugs (16)

AripiprazoleAripiprazoleAripiprazole Orally DisintegratingAripiprazoleAsenapineAsenapineBrexpiprazoleBrexpiprazoleCariprazineVraylarClozapineClozapineIloperidoneFanaptLumateperoneCaplytaOlanzapineOlanzapineOlanzapine And FuoxetineOlanzapine And FluoxetineOlanzapine And Samidorphan L-MalateLybalviPaliperidonePaliperidoneQuetiapineQuetiapineRisperidoneRisperidoneZiprasidoneZiprasidoneZiprasidone HclZiprasidone Hydrochloride

Notable Atypical Antipsychotics Interactions

Aripiprazole + Carbamazepine⛔Contraindicated

Strong CYP3A4 inducer that decreases aripiprazole exposure. Avoid use for greater than 14 days.

Aripiprazole + Clarithromycin⚠️Major

Strong CYP3A4 inhibitor increases aripiprazole exposure. Reduce aripiprazole dosage.

Aripiprazole + Fluoxetine⚠️Major

Strong CYP2D6 inhibitor increases aripiprazole exposure. Reduce aripiprazole dosage.

Aripiprazole Orally Disintegrating + Carbamazepine🟡Moderate

Strong CYP3A4 inducer that decreases aripiprazole exposure. Consider increasing aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Clarithromycin🟡Moderate

Strong CYP3A4 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Aripiprazole Orally Disintegrating + Fluoxetine🟡Moderate

Strong CYP2D6 inhibitor that increases aripiprazole exposure. Reduce aripiprazole dosage when used concomitantly.

Check Your Atypical Antipsychotics Interactions

Enter your specific medications to see all interactions — including combinations with Atypical Antipsychotics drugs.

Check Interactions →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.