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Does Macitentan And Tadalafil Interact with Nitrates?

Macitentan And Tadalafil and Nitrates have a contraindicated drug interaction according to U.S. FDA drug labeling data. Administration of nitrates within 48 hours after the last dose of OPSYNVI is contraindicated. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Macitentan And Tadalafil Class
Endothelin Receptor Antagonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Macitentan And Tadalafil and your doctor is considering prescribing Nitrates (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Macitentan And Tadalafil(Opsynvi)+💊 Nitrates

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Endothelin Receptor Antagonist
Drug B class
—
Source
NLP:macitentan and tadalafil

What this means in plain English

Administration of nitrates within 48 hours after the last dose of OPSYNVI is contraindicated.

About Macitentan And Tadalafil and Nitrates

Macitentan And Tadalafil is an Endothelin Receptor Antagonist. Macitentan And Tadalafil is also sold under the brand name Opsynvi. Macitentan And Tadalafil is taken by mouth. Macitentan And Tadalafil additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.