Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

NSAIDs reduce pain, fever, and inflammation by blocking COX enzymes. Common examples include ibuprofen, naproxen, and aspirin. They carry important interaction risks with blood thinners, ACE inhibitors, and other NSAIDs.

31 drugs in this class6 notable interactions shown

NSAIDs Drugs (31)

Acetaminophen And IbuprofenCombogesic Acetaminophen And Ibuprofen InjectionCombogesic Iv Aspirin And DipyridamoleAspirin And Dipyridamole Aspirin And Extended - Release DipyridamoleAspirin And Extended - Release Dipyridamole Capsules, 25 Mg / 200 Mg Asprin And Extended-Release DipyridamoleAsprin And Extended-Release Dipyridamole Bupivacaine And MeloxicamZynrelef Butalbital, Aspirin, And CaffeineButalbital, Aspirin, And Caffeine Butalbital, Aspirin, Caffeine And Codeine PhosphateAscomp CelecoxibConsensi DiclofenacDiclofenac Sodium DiflunisalDolobid EtodolacLodine FlurbiprofenAnsaid Hydrocodone Bitartrate And IbuprofenIbudone IbuprofenIbu Ibuprofen And FamotidineDuexis Ibuprofen OralIbuprofen IndomethacinTivorbex KetoprofenKetofen Mefenamic AcidMefenamic Acid MeloxicamMetacam Meloxicam, RizatriptanSymbravo NabumetoneRelafen NaproxenVimovo Naproxen And Esomeprazole MagnesiumVimovo Naproxen OralNaproxen Oral Suspension Naproxen SodiumAleve PM OxaprozinDaypro Oxycodone And AspirinOxycodone And Aspirin PiroxicamFeldene SulindacSulindac

Notable NSAIDs Interactions

Acetaminophen And Ibuprofen + Aspirin⚠️Major

Concomitant use of ibuprofen and aspirin increases risk of GI adverse reactions and bleeding; no greater therapeutic benefit than NSAID alone.

Acetaminophen And Ibuprofen + Warfarin⚠️Major

Ibuprofen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Acetaminophen And Ibuprofen + Furosemide🟡Moderate

NSAIDs reduce natriuretic effect of loop diuretics like furosemide in some patients.

Acetaminophen And Ibuprofen Injection + Aspirin⚠️Major

Concomitant use of NSAID and aspirin is associated with significantly increased incidence of GI adverse reactions and increased risk of bleeding.

Acetaminophen And Ibuprofen Injection + Warfarin⚠️Major

Ibuprofen and warfarin have synergistic effect on bleeding with increased risk of serious bleeding compared to either drug alone.

Acetaminophen And Ibuprofen Injection + Furosemide🟡Moderate

NSAIDs reduced the natriuretic effect of loop diuretics. Monitor renal function and fluid status during concomitant use.

Check Your NSAIDs Interactions

Enter your specific medications to see all interactions — including combinations with NSAIDs drugs.

Check Interactions →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.